Osteomyelitis is a major complication of orthopedic diseases with high recurrence and morbidity, along with long hospital stays and high medical costs. The conventional treatment of osteomyelitis involves surgical debridement followed by long-term and high-dose of systemic antibiotic therapy, which in many cases is not effective and can induces serious bacterial resistance. As an alternative strategy, local therapy has been devel-oped for treatment of osteomyelitis. In this review, we expound on the advances in the antimicrobial treatment of osteomyelitis including antimicrobial agent therapy, physical therapy and immunotherapy, which we hope to shed some light on future research of osteomyelitis treatment.
[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
[2]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped Surg, Sch Med, Shanghai 200080, Peoples R China.
[3]Shanghai Gen Hosp, Jiading Branch, Shanghai 201803, Peoples R China.
[4]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China.
[5]East China Univ Sci & Technol, Shenzhen Res Inst, Shenzhen 518063, Peoples R China.
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